*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP6300000
CHEMICAL NAME           : 2H-1,3-Oxazine-2,4(3H)-dione, 5,5-diethyldihydro-
CAS REGISTRY NUMBER     : 702-54-5
BEILSTEIN REFERENCE NO. : 0133129
REFERENCE               : 4-27-00-03263 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C8-H13-N-O3
MOLECULAR WEIGHT        : 171.22
WISWESSER LINE NOTATION : T6OVMVTJ E2 E2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dietadione
   * Diethadion
   * Diethadione
   * 5,5-Diethyldihydro-2H-1,3-oxazine-2,4(3H)-dione
   * 5,5-Diethyl-1,3-oxazin-2,4-dione
   * 5,5-Diethyl-1,3-oxazine-2,4-dione
   * 5,5-Dietildiidro-1,3-ossazin-2,4-dione
   * 5,5-Diethyltetrahydro-2H-1,3-oxazine-2,4(3H)-dione
   * Dietroxine
   * Dihydro-5,5-diethyl-2H-1,3-oxazine-2,4(3H)-dione
   * Diidro-5,5-dietil-2H-1,3-ossazin-2,4(3H)-dione
   * Dioxone
   * L 1811
   * Ledosten
   * Lepton
   * Persisten
   * TOCE
   * Tocen
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 71 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 13,244,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 13,244,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 13,244,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 81 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,282,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,281,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,281,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 13,244,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,282,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4550 mg/kg/26W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Related to Chronic Data - death
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 13,244,1961

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***