*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RP6471000 CHEMICAL NAME : 2H-1,3-Oxazine-2-thione, 3,4,5,6-tetrahydro-6-phenoxymethyl- CAS REGISTRY NUMBER : 39754-64-8 BEILSTEIN REFERENCE NO. : 0517442 LAST UPDATED : 199712 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C11-H13-N-O2-S MOLECULAR WEIGHT : 223.31 WISWESSER LINE NOTATION : T6MYOTJ BUS D1OR COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 2H-1,3-Oxazine-2-thione, 6-phenoxymethyl-3,4,5,6-tetrahydro- * 6-Phenoxymethyl-3,4,5,6-tetrahydro-2H-1,3-oxazine-2-thione * Phenoxymethyl-6 tetrahydroxazine-1,3 thione-2 * Tetrahydro-6-(phenoxymethyl)-2H-1,3-oxazine-2-thione * Tifemoxone *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2200 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Kidney, Ureter, Bladder - urine volume increased Blood - normocytic anemia REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 1,229,1978 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 11,75,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15470 mg/kg/26W-I TOXIC EFFECTS : Behavioral - aggression Skin and Appendages - hair Related to Chronic Data - death REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 1,229,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 10010 ug/kg/26W-I TOXIC EFFECTS : Liver - liver function tests impaired Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 1,229,1978 *** END OF RECORD ***