*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP6500000
CHEMICAL NAME           : 4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dio
                          ne, 8,12b-dihydro-11-chloro-2,8- dimethyl-12b-phenyl-
CAS REGISTRY NUMBER     : 27223-35-4
LAST UPDATED            : 198702
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H17-Cl-N2-O3
MOLECULAR WEIGHT        : 368.84
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Anxon
   * Ketazolam
   * U-28,774
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,293,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,293,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MDACAP Medicamentos de Actualidad.  (J.R. Prous, S.A., Apartado de Correos
   540, 08080 Barcelona, Spain)  V.1-    1965-  Volume(issue)/page/year:
   16,293,1980
 
                            *** END OF RECORD ***