*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RQ3500000
CHEMICAL NAME : 2-Oxazolidinone, 5-((o-methoxyphenoxy)methyl)-
CAS REGISTRY NUMBER : 70-07-5
BEILSTEIN REFERENCE NO. : 0530698
LAST UPDATED : 199612
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C11-H13-N-O4
MOLECULAR WEIGHT : 223.25
WISWESSER LINE NOTATION : T5MVOTJ D1OR BO1
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* AHR 233
* Alkapol peg-400
* CL 27,319
* Control-OM
* Dorsiflex
* Dorsilon
* Ekilan
* Lenetran
* Lenetran TAB
* Lenetranat
* Mefenoxalona
* Mefenoxalone
* Mephenoxalone
* Methoxadone
* Methoxydon(E)
* 5-(o-Methoxyphenoxymethyl)-2-oxazolidinone
* 5-(o-Methoxyphenoxymethyl)-2-oxazolidone
* Metoxadone
* Moderamin
* OM 518
* Oxazolidinone
* Placidex
* Riself
* Transpoise
* Trepidone
* Valanas
* Xerene
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3820 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
6,642,1964
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 134,198,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSDTAP Proceedings of the European Society for the Study of Drug Toxicity.
(Princeton, NJ 08540) V.1-15, 1963-74. For publisher information, see
PESTD5. Volume(issue)/page/year: 11,212,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RAMAAB Revista de la Asociacion Medica Argentina. (Buenos Aires, Argentina)
V.1-89, 1915-76. Discontinued. Volume(issue)/page/year: 74,82,1960
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30330 mg/kg/30D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in ovarian weight
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,220,1962
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 18 gm/kg/30D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Liver - other changes
Blood - normocytic anemia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,220,1962
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 87 gm/kg/26W-I
TOXIC EFFECTS :
Behavioral - ataxia
Blood - normocytic anemia
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
4,220,1962
*** END OF RECORD ***