*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RQ3850000
CHEMICAL NAME           : 2-Oxazolidinone, 5-((3,5-xylyloxy)methyl)-
CAS REGISTRY NUMBER     : 1665-48-1
BEILSTEIN REFERENCE NO. : 0884592
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H15-N-O3
MOLECULAR WEIGHT        : 221.28
WISWESSER LINE NOTATION : T5MVOTJ D1OR C1 E1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AHR-438
   * CL 39,148
   * 5-((3,5-Dimethylphenoxy)methyl)-2-oxazolidinone
   * Metaxalone
   * Metazalone
   * Metazolone
   * Skelaxin
   * Zorane
   * 5-((3,5-Xylyloxy)methyl)-2-oxazolidinone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 775 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,261,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 515 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,242,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1690 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - rigidity (including catalepsy)
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 233,326,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 490 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,261,1972
 
                            *** END OF RECORD ***