*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RQ4725000
CHEMICAL NAME           : 2-Oxazoline, 2-amino-5-phenyl-, fumarate (1:1)
CAS REGISTRY NUMBER     : 13425-22-4
LAST UPDATED            : 199403
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C9-H10-N2-O.C4-H4-O4
MOLECULAR WEIGHT        : 278.29
WISWESSER LINE NOTATION : T5N CO AUTJ BZ DR &OV1U1VO
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 2-Amino-5-phenyl-oxazoline formate
   * Aminorexfumarate
   * Menocil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - sympathomimetic
   Behavioral - excitement
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   26,117,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - sympathomimetic
   Behavioral - excitement
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   26,117,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - sympathomimetic
   Behavioral - excitement
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   26,117,1970
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 826 mg/kg/17W-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Vascular - BP elevation not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1057,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2541 mg/kg/30W-C
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Vascular - BP elevation not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1057,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 252 mg/kg/36D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Vascular - BP elevation not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1057,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 539 mg/kg/77D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Vascular - BP elevation not characterized in autonomic section
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 23,1057,1973
 
                            *** END OF RECORD ***