*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RT0620000
CHEMICAL NAME           : Pachycarpine
CAS REGISTRY NUMBER     : 492-08-0
BEILSTEIN REFERENCE NO. : 3540601
REFERENCE               : 5-23-05-00497 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C15-H26-N2
MOLECULAR WEIGHT        : 234.43
WISWESSER LINE NOTATION : T C66 K66 A HN PNTJ
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * (+)-Sparteine
   * d-Sparteine
   * 6-alpha,7-beta,9-beta,11-beta-Sparteine
   * Sparteine, d-isomer
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 89100 ug/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   SHIYDO Shaanxi Xinyiyao.  Shaanxi New Medical.  (Shaanxi Renmin Chubanshe,
   Xi'an, Shaanxi, Peop. Rep. China)  V.1-    1972-  Volume(issue)/page/year:
   11(6),53,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 21(5),46,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   32ZCAI "Ganglion-Blocking and Ganglion-Stimulation Agents," Kharkevich,
   D.A., Moscow, First Moscow Medical Institute, 1967 Volume(issue)/page/year:
   -,175,1967
 
                            *** END OF RECORD ***