*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RU4736000
CHEMICAL NAME           : Pantothenic acid, D-, compd. with streptomycin (1:1)
CAS REGISTRY NUMBER     : 6227-52-7
LAST UPDATED            : 199503
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H39-N7-O12.C9-H17-N-O5
MOLECULAR WEIGHT        : 800.94
WISWESSER LINE NOTATION : QV2MVYQX1&1&1Q &T6OTJ B1Q CQ DQ EM1 FO- CT5OTJ DVH DQ
                          E1 BO- AL6TJ BQ CQ DMYZUM EQ FMYZUM
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * SM-Pantothenat
   * S-Pantothenat
   * Streptomycin-pantothenate
   * Streptothenate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 388 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABANAE Antibiotics Annual.  (New York, NY)  1953-60.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: 4,574,1956/1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 229 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 6,585,1956
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 2400 mg/kg/24D-I
TOXIC EFFECTS :
   Behavioral - ataxia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 6,379,1956
 
                            *** END OF RECORD ***