*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RV0450000 CHEMICAL NAME : Paraffin waxes and hydrocarbon waxes, chlorinated CAS REGISTRY NUMBER : 63449-39-8 LAST UPDATED : 199710 DATA ITEMS CITED : 14 COMPOUND DESCRIPTOR : Primary Irritant SYNONYMS/TRADE NAMES : * Cerechlor 54 * Cereclor * Cereclor 30 * Cereclor 42 * Cereclor 48 * Cereclor 52 * Cereclor 54 * Cereclor 70 * Cereclor 51L * Cereclor 56L * Cereclor 63L * Cereclor 65L * Cereclor 70L * Cereclor 50LV * Cereclor S 42 * Cereclor S52 * Cereclor S70 * Chlorcosane * Chlorez 700 * Chlorez 700HMP * Chlorinated paraffins * Chloroparaffine 40G * Chlorowax * Chlorowax 40 * Chlorowax 50 * Chlorowax 70 * Chlorowax 500C * Chlorowax 70S * Chlorowax S 70 * Clorafin * Crechlor S 45 * Flexchlor * NCI-C53587 * Paroil chlorez * Unichlor * Unichlor 50 *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 100 mg/24H REACTION SEVERITY : Mild REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,514,1980 TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg REACTION SEVERITY : Mild REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,514,1980 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >21500 uL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 5,786,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >10 mL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978 Volume(issue)/page/year: 5,786,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 mg/kg/90D-C TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,514,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14 gm/kg/14D-I TOXIC EFFECTS : Liver - changes in liver weight Endocrine - other changes Biochemical - Effect on specific coenzyme - CoA REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 77,81,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3500 mg/kg/14D-I TOXIC EFFECTS : Liver - changes in liver weight Biochemical - Effect on specific coenzyme - CoA REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 77,81,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 9 gm/kg/90D-C TOXIC EFFECTS : Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 54,514,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5417 No. of Facilities: 27695 (estimated) No. of Industries: 202 No. of Occupations: 119 No. of Employees: 573193 (estimated) No. of Female Employees: 38354 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9112;8EHQ-0892-9113 EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9114 EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***