*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RY1105000 CHEMICAL NAME : Pemoline magnesium CAS REGISTRY NUMBER : 18968-99-5 LAST UPDATED : 199712 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C9-H10-Mg-N2-O4 MOLECULAR WEIGHT : 234.52 WISWESSER LINE NOTATION : T5OYMV EHJ BUM ER &-MG- COMPOUND DESCRIPTOR : Human SYNONYMS/TRADE NAMES : * Abbott 30400 * Bis(aquo)-N,N'-(2-imino-5-phenyl-4-oxazolidinone)magnesium (II) * Cylert * (2-Imino-5-phenyl-4-oxazolidinonato(2-))diaquomagnesium * 2-Imino-5-phenyl-4-oxazolidinone magnesium chelate * Magnesium pemoline * 4-Oxazolidinone, 2-imino-5-phenyl-, mixt. with magnesium hydroxide * 4(5H)-Oxazolidinone, 2-imino-5-phenyl-, mixt. with magnesium hydroxide * Pemoline magnesium chelate * Pemolin and magnesium hydroxide * Tamilan *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 149 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Gastrointestinal - nausea or vomiting REFERENCE : CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 18,761,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 485 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,810,1973 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - irritability Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,441,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 487 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,441,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - changes in motor activity (specific assay) Skin and Appendages - hair REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 181,441,1969 *** END OF RECORD ***