*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RY4410000 CHEMICAL NAME : Penicillin, compd. with 9-aminoacridine, hydrochloride LAST UPDATED : 199107 DATA ITEMS CITED : 3 WISWESSER LINE NOTATION : T C666 BNJ IZ &GH &T45 ANV ESTJ CMV1R& F1 F1 GVQ COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * 9-Aminoacridinepenicillin hydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 78 mg/kg TOXIC EFFECTS : Vascular - regional or general arteriolar or venous dilation Liver - change in gall bladder structure or function Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,498,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Vascular - regional or general arteriolar or venous dilation Liver - change in gall bladder structure or function Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,498,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Vascular - regional or general arteriolar or venous dilation Liver - change in gall bladder structure or function Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 38,498,1949 *** END OF RECORD ***