*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RY4410000
CHEMICAL NAME           : Penicillin, compd. with 9-aminoacridine,
                          hydrochloride
LAST UPDATED            : 199107
DATA ITEMS CITED        : 3
WISWESSER LINE NOTATION : T C666 BNJ IZ &GH &T45 ANV ESTJ CMV1R& F1 F1 GVQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 9-Aminoacridinepenicillin hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - change in gall bladder structure or function
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 38,498,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - change in gall bladder structure or function
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 38,498,1949
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - change in gall bladder structure or function
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 38,498,1949
 
                            *** END OF RECORD ***