*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RZ2620000 CHEMICAL NAME : Pentaerythritol, tetranitrate CAS REGISTRY NUMBER : 78-11-5 OTHER CAS REGISTRY NOS. : 108736-71-6 BEILSTEIN REFERENCE NO. : 1716886 REFERENCE : 4-01-00-02816 (Beilstein Handbook Reference) LAST UPDATED : 199701 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C5-H8-N4-O12 MOLECULAR WEIGHT : 316.17 WISWESSER LINE NOTATION : WNO1X1ONW1ONW1ONW COMPOUND DESCRIPTOR : Tumorigen Drug Mutagen Human SYNONYMS/TRADE NAMES : * Angicap * Angitet * Antora * Arcotrate * Baritrate * 2,2-Bis((nitrooxy)methyl)-1,3-propanediol dinitrate (ester) * 2,2-Bis(hydroxymethyl)-1,3-propanediol tetranitrate * CHOT * Deltrate-20 * 1,3-Dinitrato-2,2-bis(nitratomethyl)propane * Duotrate * El PETN * Erinit * Hasethrol * Kaytrate * Lowetrate * Martrate-45 * Metranil * Mikardol * Mycardol * Myotrate "10" * NCI-C55743 * Neo-corovas * Neopentanetetrayl nitrate * Niperyt * Niperyth * Nitrinol * Nitropenta * Nitropentaerythrite * Nitropentaerythritol * Pencard * Pentafin * Pentanitrine * Pentarit * Pentestan-80 * Pentetrate unicelles * Penthrit * Penthrite * Pentitrate * Pentrate * Pentriol * Pentritol * Pentryate * Pentryate 80 * Pergitral * Peridex-LA * Peritrate * Perityl * PETN * Prevangor * 1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, dinitrate (ester) * Quintrate * Rythritol * SDM No. 23 * SDM No. 35 * Subicard * Tanipent * Tentrate-20 * Tetranitropentaerythrite * Tetrasule * Tranite D-lay * Vasitol * Vasodiatol * Vaso-80 unicelies *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 1669 mg/kg/8Y-C TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951- Volume(issue)/page/year: 87,498,1972 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: 16(2),63,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Vascular - regional or general arteriolar or venous dilation REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 131,187,1961 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 12875 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - thyroid tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-365,1989 ** MUTATION DATA ** TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 160 mg/L REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-365,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83538 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83538 No. of Facilities: 59 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 2650 (estimated) No. of Female Employees: 1267 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY NTP Carcinogenesis Studies (feed);equivocal evidence:rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-365,89 NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-365,89 *** END OF RECORD ***