*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SA0370000
CHEMICAL NAME           : Pentane, 1,2:4,5-diepoxy-
CAS REGISTRY NUMBER     : 4051-27-8
LAST UPDATED            : 199712
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C5-H8-O2
MOLECULAR WEIGHT        : 100.13
WISWESSER LINE NOTATION : T3OTJ B1- BT3OTJ
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1,2,4,5-Diepoxypentane
   * 2,2'-Methylenebisoxirane
   * Oxirane, 2,2'-methylenebis-
   * 1:4-Pentadiene dioxide
   * Pentitol, 1,2:4,5-dianhydro-3-deoxy-
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 gm/kg/58W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   35,707,1965
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 76 gm/kg/63W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   14JTAF "Mycotoxins in Foodstuffs, Proceedings of the Symposium held at the
   Massachusetts Institute of Technology, 1964," Wogan, G.N., ed., Cambridge,
   MA, MIT Press, 1965  Volume(issue)/page/year: -,275,1965
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 75 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,1890,1972
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 250 mg/kg
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 6,235,1951
 
                            *** END OF RECORD ***