*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SB2145000
CHEMICAL NAME           : 4-Pentenamide, 2,2-diethyl-
CAS REGISTRY NUMBER     : 512-48-1
BEILSTEIN REFERENCE NO. : 1761844
REFERENCE               : 3-02-00-01351 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C9-H17-N-O
MOLECULAR WEIGHT        : 155.27
WISWESSER LINE NOTATION : ZVX2&2&2U1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * Diaethylallylacetamide
   * Diethylallylacetamide
   * Epinoval
   * Novonal
   * Valdetamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Cardiac - other changes
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 102,1591,1977
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 102,1591,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 102,1591,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 217 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ITMZBJ Intensivmedizin.  (Dr. Dietrich Steinkopff Verlag, Postfach 11-10-08,
   D-6100 Darmstadt 11, Fed. Rep. Ger.)  V.1-    1964- Volume(issue)/page/year:
   17,305,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LDTU** "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten,
   Dissertation," Leube, F., Pharmakologischen Institut der Universitat
   Tubingen, Fed. Rep. Ger., 1931  Volume(issue)/page/year: -,-,1931
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 102,1591,1977
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LDTU** "Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten,
   Dissertation," Leube, F., Pharmakologischen Institut der Universitat
   Tubingen, Fed. Rep. Ger., 1931  Volume(issue)/page/year: -,-,1931
 
                            *** END OF RECORD ***