*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SB2270000
CHEMICAL NAME           : 4-Pentenenitrile, 3-hydroxy-
CAS REGISTRY NUMBER     : 27451-36-1
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C5-H7-N-O
MOLECULAR WEIGHT        : 97.13
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * 1-Cyano-2-hydroxy-3-butene
   * 3-Hydroxy-4-pentenenitrile
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 39,311,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 800 mg/kg/4D-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of endocrine pancreas
   Kidney, Ureter, Bladder - other changes in urine composition
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   26,137,1988
 
                            *** END OF RECORD ***