*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SC1235500
CHEMICAL NAME           : Pentylamine, N-nitroso-N-(nitrosomethyl)-
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C6-H13-N3-O2
MOLECULAR WEIGHT        : 159.22
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * MPN
   * N-Nitrosomethylpentylnitrosamine
   * N-Nitroso-N-(nitrosomethyl)pentylamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of esophagus
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   SACAB7 South African Cancer Bulletin.  (National Cancer Assoc. of South
   Africa, 9 Jubillee Rd., Parktown, Johannesburg, S. Africa)  V.1-    1957-
   Volume(issue)/page/year: 25,66,1981
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of esophagus
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   SACAB7 South African Cancer Bulletin.  (National Cancer Assoc. of South
   Africa, 9 Jubillee Rd., Parktown, Johannesburg, S. Africa)  V.1-    1957-
   Volume(issue)/page/year: 25,66,1981
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   SACAB7 South African Cancer Bulletin.  (National Cancer Assoc. of South
   Africa, 9 Jubillee Rd., Parktown, Johannesburg, S. Africa)  V.1-    1957-
   Volume(issue)/page/year: 25,66,1981
 
                            *** END OF RECORD ***