*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SF7300000
CHEMICAL NAME           : 2-Phenanthrenecarboxylic acid,
                          1-ethyl-1,2,3,4-tetrahydro-7-methoxy-2-methyl-,
                          cis-(+-)-
CAS REGISTRY NUMBER     : 5684-13-9
LAST UPDATED            : 198910
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C19-H22-O3
MOLECULAR WEIGHT        : 298.41
WISWESSER LINE NOTATION : L B666&&TJ EO1 K2 LVQ L
COMPOUND DESCRIPTOR     : Tumorigen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Bisdehydroisynolic acid methyl ester
   * Dehydrofolliculinic acid
   * Doisynoestrol
   * 1-Ethyl-2-methyl-7-methoxy-1,2,3,4-tetrahydrophenanthryl-2-carboxylic  
   acid
   * Fenocyclin
   * Fenocycline
   * 7-Methylbisdehydrodoisynolic acid
   * Metilester del acido bisdehidroisynolico
   * 16,17-Seco-13-alpha-estra-1,3,5,6,7,9-pentaen-17-oic acid, methyl ester
   * Surestrine
   * Surestryl
   * Tetradehydrodoisynolic acid methyl ether
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3952 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   BSBSAS Boletin de la Sociedad de Biologia de Santiago de Chile. (Santiago,
   Chile)  V.1-12, 1943-55. Discontinued.  Volume(issue)/page/year: 8,142,1951
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 437 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   12,274,1952
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 ug/kg
SEX/DURATION            : female 5 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 14,487,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 4-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 14,487,1976
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 160 mg/kg
SEX/DURATION            : male 54 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   57,255,1955
 
                            *** END OF RECORD ***