*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SA9080000
CHEMICAL NAME           : 2-Pentanone,
                          1-(5-(3-furyl)-2-methyl-tetrahydro-2-furyl)-4-methyl-
                          , (2R,5S)-(-)-
CAS REGISTRY NUMBER     : 581-12-4
OTHER CAS REGISTRY NOS. : 50884-35-0
LAST UPDATED            : 199606
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C15-H22-O3
MOLECULAR WEIGHT        : 250.37
WISWESSER LINE NOTATION : T5OTJ B1V1Y1&1 B1 E- CT5OJ
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * 1-(5-(3-Furyl)tetrahydro-2-methyl-2-furyl)-4-methyl-2-pentanone,  
   (2R,5S)-(-)
   * Ngaione
   * (-)-Ngaione
   * cis-Ngaione
   * 2-Pentanone,  
   4-methyl-1-(2,3,4,5-tetrahydro-5-methyl-(2,3'-bifuran)-5-yl)-, (2S-cis)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AJCHAS Australian Journal of Chemistry.  (Commonwealth Scientific and
   Industrial Research Organization, 314 Albert St., E. Melbourne, Vic. 3002,
   Australia)  V.6-    1953-  Volume(issue)/page/year: 23,107,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 153 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   NSYPAS Nongsa Sihom Yongu Pogo.  Research Reports on Agricultural
   Experimentation.  (Suwon, S. Korea) V.1-26, 1958-84.
   Volume(issue)/page/year: 26(2),64,1984
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Liver - hepatitis (hepatocellular necrosis), zonal
REFERENCE :
   BJEPA5 British Journal of Experimental Pathology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.1-    1920-  Volume(issue)/page/year:
   53,242,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 188 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   NSYPAS Nongsa Sihom Yongu Pogo.  Research Reports on Agricultural
   Experimentation.  (Suwon, S. Korea) V.1-26, 1958-84.
   Volume(issue)/page/year: 26(2),64,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11347 mg/kg/7W-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 1(3),165,1981
 
                            *** END OF RECORD ***