*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SF7960000
CHEMICAL NAME           : Phenanthridinium, 3,8-diamino-5-ethyl-6-phenyl-,
                          chloride
CAS REGISTRY NUMBER     : 602-52-8
LAST UPDATED            : 199606
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C21-H20-N3.Cl
MOLECULAR WEIGHT        : 349.89
WISWESSER LINE NOTATION : T B666 HKJ EZ H2 IR& LZ &Q &G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Babidium chloride
   * 3,8-Diamino-5-ethyl-6-phenylphenanthridinium chloride
   * 2,7-Diamino-9-phenyl-10-ethylphenanthridinium chloride
   * Ethidium chloride
   * Homidium chloride
   * Novidium chloride
   * NSC-84423
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,107,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,107,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56370 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,107,1965
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 17640 ug/kg/28D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,107,1965
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 17640 ug/kg/28D-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,107,1965
 
                            *** END OF RECORD ***