*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SG1593000
CHEMICAL NAME           : Phenazinium,
                          3-amino-7-((p-(dimethylamino)phenyl)azo)-5-phenyl-,
                          chloride
CAS REGISTRY NUMBER     : 4618-88-6
LAST UPDATED            : 199410
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C26-H23-N6.Cl
MOLECULAR WEIGHT        : 455.00
WISWESSER LINE NOTATION : T C666 BK INJ BR& EZ MNUNR DN1&1 &G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 3-Amino-7-((p-(dimethylamino)phenyl)azo)-5-phenylphenazinium chloride
   * C.I. 11045
   * Janus Green
   * Janus Green G
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18900 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12960 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4810 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MGGEAE Molecular and General Genetics.  (Springer-Verlag, Heidelberger Pl.
   3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.99-    1967-
   Volume(issue)/page/year: 144,75,1976

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay

 
                            *** END OF RECORD ***