*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SG1623000 CHEMICAL NAME : Phenazinium, 3,7-diamino-2,8-dimethyl-5-phenyl-, chloride CAS REGISTRY NUMBER : 477-73-6 LAST UPDATED : 199701 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C20-H19-N4.Cl MOLECULAR WEIGHT : 350.88 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * Basic Red 2 * Brilliant safranine BR * Brilliant safranine G * Brilliant safranine GR * Calcozine Red Y * Cerven zasadita 2 * C.I. 50240 * C.I. Basic Red 2 * 2,8-Dimethylphenosafranine * Gossypimine * Hidaco safranine * Leather Red HT * Mitsui safranine * Nippon kagaku safranine GK * Nippon kagaku safranine T * Safranin * Safranine * Safranine A * Safranine B * Safranine G * Safranine GF * Safranine J * Safranine O * Safranine OK * Safranine superfine G * Safranine T * Safranine TH * Safranine TN * Safranine Y * Safranine YN * Safranine ZH * Safranin T * Tolusafranine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28740 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 69,327,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 24020 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 26940 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 16 ug/plate REFERENCE : TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,153,1976 TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 4 ug/well REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,429,1981 TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 2 mg/disc REFERENCE : TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,153,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1441 No. of Facilities: 1027 (estimated) No. of Industries: 9 No. of Occupations: 18 No. of Employees: 4314 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1441 No. of Facilities: 1253 (estimated) No. of Industries: 6 No. of Occupations: 10 No. of Employees: 22263 (estimated) No. of Female Employees: 14330 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***