*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SH1050000
CHEMICAL NAME : Phenethylamine, p-chloro-alpha,alpha-dimethyl-
CAS REGISTRY NUMBER : 461-78-9
BEILSTEIN REFERENCE NO. : 1099928
REFERENCE : 4-12-00-02823 (Beilstein Handbook Reference)
LAST UPDATED : 199709
DATA ITEMS CITED : 15
MOLECULAR FORMULA : C10-H14-Cl-N
MOLECULAR WEIGHT : 183.70
WISWESSER LINE NOTATION : ZX1&1&1R DG
COMPOUND DESCRIPTOR : Drug
Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* p-Chloro-alpha,alpha-dimethylphenethylamine
* Chlorophentermine
* beta-(p-Chlorophenyl)-alpha,alpha-dimethylethylamine
* 1-(p-Chlorophenyl)-2-methyl-2-aminopropane
* Chlorphenteramine
* Chlorphentermine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 5357 ug/kg
TOXIC EFFECTS :
Autonomic Nervous System - sympathomimetic
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 34,205,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
65(6),218S,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 270 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
APPFAR Acta Poloniae Pharmaceutica (English Translation). Translation of
APPHAX. (Warsaw, Poland) V.20-29, 1963-72. Discontinued.
Volume(issue)/page/year: 26,598,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska
Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964-
Volume(issue)/page/year: 15,87,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 260 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
APPFAR Acta Poloniae Pharmaceutica (English Translation). Translation of
APPHAX. (Warsaw, Poland) V.20-29, 1963-72. Discontinued.
Volume(issue)/page/year: 26,598,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#00697
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1800 mg/kg/30D-I
TOXIC EFFECTS :
Behavioral - food intake (animal)
Behavioral - fluid intake
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
APPFAR Acta Poloniae Pharmaceutica (English Translation). Translation of
APPHAX. (Warsaw, Poland) V.20-29, 1963-72. Discontinued.
Volume(issue)/page/year: 26,598,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 720 mg/kg/6W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,2096,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1800 mg/kg/15W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,2096,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1800 mg/kg/6W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,2096,1972
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3900 mg/kg/13W-I
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,2096,1972
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 480 mg/kg
SEX/DURATION : female 10-21 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including
somatic cell genetic material)
Reproductive - Specific Developmental Abnormalities - immune and
reticuloendothelial system
REFERENCE :
VAAZA2 Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1968-
Volume(issue)/page/year: 12,295,1973
** MUTATION DATA **
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 300 mg/kg/5D (Continuous)
REFERENCE :
40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology
as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan,
eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year:
-,459,1978
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 300 mg/kg/5D (Continuous)
REFERENCE :
40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology
as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan,
eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year:
-,459,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 35,89,1976
*** END OF RECORD ***