*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SH4910000
CHEMICAL NAME           : Phenethylamine, N,alpha-dimethyl-, (S)-(+)-
CAS REGISTRY NUMBER     : 537-46-2
LAST UPDATED            : 199707
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H15-N
MOLECULAR WEIGHT        : 149.26
WISWESSER LINE NOTATION : 1MY1&1R  -D
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Benzeneethanamine, N,alpha-dimethyl-, (S)-
   * d-Deoxyephedrine
   * (+)-(S)-Deoxyephedrine
   * d-Desoxyephedrine
   * d-N,alpha-Dimethylphenethylamine
   * (+)-Methamphetamine
   * d-Methamphetamine
   * d-(S)-Methamphetamine
   * L-Methamphetamine
   * S-(+)-Methamphetamine
   * (+)-Methylamphetamine
   * d-Methylamphetamine
   * d-N-Methylamphetamine
   * N-Methylamphetamine
   * (+)-N-Methylamphetamine
   * Methyl-beta-phenylisopropylamine
   * d-1-Phenyl-2-methylaminopropan
   * Norodin
   * d-1-Phenyl-2-methylaminopropane
   * d-Phenylisopropylmethylamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 195,647,1940
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 14 mg/kg/7D-I
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - monoamine oxidase
   Biochemical - Metabolism (Intermediary) - effect on mitochondrial function
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 45,79,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 240 mg/kg
SEX/DURATION            : female 13-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   DABBBA Dissertation Abstracts International, B: The Sciences and
   Engineering.  (University Microfilms International, 300 N. Zeeb Rd., Ann
   Arbor, MI 48106)  V.30-    1969-  Volume(issue)/page/year: 54,4003,1994
 
                            *** END OF RECORD ***