*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SH5450000
CHEMICAL NAME           : Phenethylamine, N,alpha-dimethyl-, hydrochloride,
                          (+-)-
CAS REGISTRY NUMBER     : 4298-16-2
LAST UPDATED            : 199712
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C10-H15-N.Cl-H
MOLECULAR WEIGHT        : 185.72
WISWESSER LINE NOTATION : 1MY1&1R &GH -R
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Benzeneethanamine, N,alpha-dimethyl-, hydrochloride, (+-)-
   * dl-Deoxyephedrine hydrochloride
   * dl-Desoxyephedrine hydrochloride
   * dl-Methanphetamine hydrochloride
   * dl-N-Methyl-beta-phenylisopropylamine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 54480 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 37,223,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 37,223,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 57190 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JANCA2 Journal of the Association of Official Analytical Chemists.  (Assoc.
   of Official Analytical Chemists, 1111 N. 19th St., Suite 210, Arlington, VA
   22209)  V.49-    1966-  Volume(issue)/page/year: 68,1213,1985
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg/98D-I
TOXIC EFFECTS :
   Cardiac - cardiomegaly
   Gastrointestinal - other changes
   Related to Chronic Data - death
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 37,223,1948
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 84 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA
   10158-0012)  V.1-    1987-  Volume(issue)/page/year: 13,241,1993
 
                            *** END OF RECORD ***