*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : SH5455000
CHEMICAL NAME : Phenethylamine, N,alpha-dimethyl-, hydrochloride,
(S)-(+)-
CAS REGISTRY NUMBER : 51-57-0
OTHER CAS REGISTRY NOS. : 51176-61-5
LAST UPDATED : 199706
DATA ITEMS CITED : 13
MOLECULAR FORMULA : C10-H15-N.Cl-H
MOLECULAR WEIGHT : 185.72
WISWESSER LINE NOTATION : 1MY1R &GH
COMPOUND DESCRIPTOR : Tumorigen
Drug
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Adipex
* Benzeneethanamine, N,alpha-dimethyl-, hydrochloride, (S)-
* Deofed
* d-Deoxyephedrine hydrochloride
* d-Desoxyephedrine hydrochloride
* Desoxyfed
* Desoxyn
* Destim
* Desyphed
* Dexoval
* Dextim
* Doxyfed
* Drinalfa
* Efroxine
* Eufodrinal
* Gerovit
* Isophen
* (+)-Methamphetamine chloride
* (+)-Methamphetamine hydrochloride
* d-Methamphetamine hydrochloride
* Methamphetaminium chloride
* Methylamphetamine hydrochloride
* d-Methylamphetamine hydrochloride
* N-Methylamphetamine hydrochloride
* Methylisomyn
* d-N-Methyl-beta-phenylisopropylamine hydrochloride
* Norodin hydrochloride
* Pervitin
* Philopon
* Soxysympamine
* Syndrox
* Tonedron
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10930 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 253,466,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,346,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 7560 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 87,214,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 6300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#02170
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co.,
Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
Volume(issue)/page/year: 84,351,1954
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 400 mg/kg
female 1-21 day(s) after conception
lactating female 19 day(s) post-birth
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
REFERENCE :
EAGRDS Experimental Aging Research. (Beech Hill Pub. Co., POB 136,
Southwest Harbor, ME 04679) V.1- 1975- Volume(issue)/page/year:
5,509,1979
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 792 mg/kg
SEX/DURATION : male 4 week(s) pre-mating
female 4 week(s) pre-mating - 3 week(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas,
New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 20,625,1973
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 13-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
Reproductive - Specific Developmental Abnormalities - endocrine system
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA
10158-0012) V.1- 1987- Volume(issue)/page/year: 15,198,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 17 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon
Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo,
Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year:
46,126,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 19 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon
Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo,
Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year:
46,126,1992
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6179
No. of Facilities: 28 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 1579 (estimated)
No. of Female Employees: 1099 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***