*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SJ5800000 CHEMICAL NAME : Phenol, 2-amino-4,6-dinitro- CAS REGISTRY NUMBER : 96-91-3 BEILSTEIN REFERENCE NO. : 0989416 REFERENCE : 4-13-00-00909 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C6-H5-N3-O5 MOLECULAR WEIGHT : 199.14 WISWESSER LINE NOTATION : WNR CZ DQ ENW COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * Acide picramique * C.I. Oxidation Base 21 * 4,6-Dinitro-2-aminophenol * Fourrine 93 * Fourrine 4R * Furro 4R * Picramic acid * Zoba 4R *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 53,58,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Gastrointestinal - hypermotility, diarrhea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,20,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 50,20,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - body temperature increase REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 53,58,1935 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 5 umol/plate REFERENCE : NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 38,533,1983 *** END OF RECORD ***