*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SL0580000 CHEMICAL NAME : Phenol, 4,4'-(diethylideneethylene)di- CAS REGISTRY NUMBER : 84-17-3 LAST UPDATED : 199512 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H18-O2 MOLECULAR WEIGHT : 266.36 WISWESSER LINE NOTATION : QR DYU2&YU2&R DQ COMPOUND DESCRIPTOR : Tumorigen Mutagen Reproductive Effector Hormone SYNONYMS/TRADE NAMES : * Agaldog * 3,4-Bis(p-hydroxyphenyl)-2,4-hexadiene * 3,4-Bis(4-hydroxyphenyl)-2,4-hexadiene * Cycladiene * Dehydrostilbestrol * Dehydrostilboestrol * Dienestrol * Dienoestrol * beta-Dienoestrol * Dienol * 4,4'-(1,2-Diethylidene-1,2-ethanediyl)bisphenol * p,p'-(Diethylideneethylene)diphenol * 4,4'-(Diethylideneethylene)diphenol * Dinovex * Di(p-oxyphenyl)-2,4-hexadiene * DV * Estragard * Estrodienol * Estroral * Follidiene * Follormon * Gynefollin * Mesohexestrol * Hormofemin * 4,4'-Hydroxy-gamma,delta-diphenyl-beta,delta-hexadiene * Oestrasid * Oestrodiene * Oestroral * Oestrovis * Para-dien * Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis- * Restrol * Retalon * Sexadien * Teserene * Willnestrol *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 40 ug/kg SEX/DURATION : female 3 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 13,101,1967 ** MUTATION DATA ** TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Fibroblast DOSE/DURATION : 5 nmol/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 281,392,1979 TYPE OF TEST : Unscheduled DNA synthesis ROUTE OF EXPOSURE : Subcutaneous TEST SYSTEM : Rodent - mouse DOSE/DURATION : 400 mg/kg REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 48,14,1988 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 3 mg/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,184,1984 TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Rodent - hamster Fibroblast DOSE/DURATION : 75 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,31,1986 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,278,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83633 No. of Facilities: 124 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 2882 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83633 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated) *** END OF RECORD ***