*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SL0810000
CHEMICAL NAME           : Phenol, 2,6-diisopropyl-
CAS REGISTRY NUMBER     : 2078-54-8
BEILSTEIN REFERENCE NO. : 1866484
REFERENCE               : 4-06-00-03435 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C12-H18-O
MOLECULAR WEIGHT        : 178.30
WISWESSER LINE NOTATION : QR BY1&1 FY1&1
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * 2,6-Bis(1-methylethyl)phenol
   * Diprivan
   * 2,6-Diisopropylphenol
   * ICI 35868
   * Phenol, 2,6-bis(1-methylethyl)-
   * Propofol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 386 mg/kg/14D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
   CCMDC7 Critical Care Medicine.  (Williams & Wilkins, 428 E. Preston Street,
   Baltimore, MD 21202) V.1-    1973-  Volume(issue)/page/year: 23,1928,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 2857 ug/kg/1D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - rigidity (including catalepsy)
   Behavioral - irritability
REFERENCE :
   ANASAB Anaesthesia.  (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1
   7DX, UK)  V.1-    1946-  Volume(issue)/page/year: 43,170,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,953,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 21,11,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,953,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMPCAS Journal of Medicinal and Pharmaceutical Chemistry.  (Washington, DC)
   V.1-5, 1959-62.  For publisher information, see JMCMAR.
   Volume(issue)/page/year: 2,201,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - analgesia
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,1350,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - sleep
   Behavioral - muscle weakness
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 23,1350,1980
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 2800 ug/kg
SEX/DURATION            : female 39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - Apgar score (human only)
   Reproductive - Effects on Newborn - other neonatal measures or effects
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   BJANAD British Journal of Anesthesia.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1923-  Volume(issue)/page/year:
   62,649,1989

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***