*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SL8400000
CHEMICAL NAME           : Phenol, p-(2-(methylamino)propyl)-
CAS REGISTRY NUMBER     : 370-14-9
LAST UPDATED            : 199603
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H15-N-O
MOLECULAR WEIGHT        : 165.26
WISWESSER LINE NOTATION : QR D1Y1&M1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Epifen
   * Foledrin
   * p-Hydroxy-N,alpha-dimethylphenethylamine
   * p-Hydroxymethamphetamine
   * p-Hydroxy-N-methylbenzedrine
   * beta-(p-Hydroxyphenyl)isopropylmethylamine
   * alpha-(p-Hydroxyphenyl)-beta-methylaminopropane
   * 1-(p-Hydroxyphenyl)-2-methylaminopropane
   * Isodrine
   * Isodrinum
   * Knoll H75
   * p-(2-Methylaminopropyl)phenol
   * N-Methylparedrine
   * beta(p-Oxy-phenyl)isopropylmethylamin
   * 1-(p-Oxyphenyl)-2-methylaminopropan
   * alpha-(p-Oxyphenyl)-beta-methyl aminopropane
   * Paredrinol
   * Phenethylamine, p-hydroxy-N,alpha-dimethyl-
   * Pholedrine
   * Pholetone
   * Pressitan
   * Promethin
   * Prometin
   * Pulsotyl
   * Stimatone
   * Sympropamin
   * Syncordan
   * Terapinyl
   * Varitol
   * Veritain
   * Veritol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in psychophysiological tests
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 159,442,1966
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,101,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 119 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 3,328,1953
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 195,647,1940
 
                            *** END OF RECORD ***