*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BP7600000
CHEMICAL NAME           : Ammonium, diethyl(2-hydroxyethyl)methyl-, bromide,
                          3-methyl-2-phenylvalerate
CAS REGISTRY NUMBER     : 90-22-2
LAST UPDATED            : 199106
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C19-H32-N-O2.Br
MOLECULAR WEIGHT        : 386.43
WISWESSER LINE NOTATION : 2Y1&YR&VO2K2&2&1 &E
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-Diethylaminoethyl 3-methyl-2-phenylvalerate methylbromide
   * 2-Diethylaminoethyl 2-phenyl-3-methylvalerate methyl bromide
   * Diethyl(2-hydroxyethyl)methyl-ammonium bromide 3-methyl-2-phenylvalerate
   * Diethyl(2-hydroxyethyl)methylammonium 3-methyl-2-phenylvalerate bromide
   * Ediposin
   * Epidosin
   * Epidozin
   * Ethanaminium, 2-((3-methyl-2-phenylvaleryl)oxy)-N,N-diethyl-N-methyl-,  
   bromide
   * 3-Methyl-2-phenylvaleric acid 2-diethylaminoethyl ester methyl bromide
   * 3-Methyl-2-phenylvaleric acid diethyl(2-hydroxyethyl)methylammonium  
   bromide ester
   * Murel
   * Phenylmethylvaleriansaeure-beta-diaethylaminoaethylester-brommethylat
   * Resitan
   * Valeric acid, 3-methyl-2-phenyl-, ester with  
   diethyl(2-hydroxyethyl)methylammonium bromide
   * Valethamate
   * Valethamate bromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,352,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 575 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,352,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,352,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,599,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,245,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,352,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 9500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,123,1969
 
                            *** END OF RECORD ***