*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BP8076000
CHEMICAL NAME           : Ammonium,
                          diethylmethyl(2-(alpha-methyl-alpha-5-norbornen-2-ylb
                          enzyloxy)ethyl)-, bromide
CAS REGISTRY NUMBER     : 29546-59-6
LAST UPDATED            : 199201
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C22-H34-N-O.Br
MOLECULAR WEIGHT        : 408.48
WISWESSER LINE NOTATION : T6KTJ A1 A1- DT5O COTJ BR& B- AL6TJ &E
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Adamon
   * ASTA 3746
   * 2-((2.2.1)-Bicyclohept-2-en-5-yl-1-phenylethoxy)ethyldiethylmethyl  
   ammonium bromide
   * Ciclonium bromide
   *   Diethylmethyl(2-(alpha-methyl-alpha-5-norbornen-2-ylbenzyloxy)ethyl)ammo
     nium bromide
   * Ethanaminium,  
   2-(bicyclo(2.2.1)hept-5-en-2-yl-1-phenylethoxy)-N,N-diethyl-N-methyl-,  
   bromide
   * 2-(1-Norbornen-5-yl-1-phenylethoxy)triethylamine methobromide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1030 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,1005,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 44 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,1005,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,1005,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,1005,1967
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 46400 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Behavioral - altered sleep time (including change in righting reflex)
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 17,1005,1967
 
                            *** END OF RECORD ***