*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BQ1140000
CHEMICAL NAME           : Ammonium,
                          (4-(p-(dimethylamino)-alpha-(p-(ethyl(m-sulfobenzyl)a
                          mino)phenyl)benzylide ne)-
                          2,5-cyclohexadien-1-ylidene)ethyl(m-sulfobenzyl)-,
                          hydroxide, inner salt, sodium salt
CAS REGISTRY NUMBER     : 1694-09-3
LAST UPDATED            : 199707
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C39-H41-N3-O6-S2.Na
MOLECULAR WEIGHT        : 734.94
WISWESSER LINE NOTATION : L6Y DYJ AUYR DN1&1&R DN2&1R CSWQ&& DUK2&1R CSNO &-NA-
                          &38/47
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acid Fast Violet 5BN
   * Acid Violet
   * Acid Violet 49
   * Acid Violet 5B
   * Acid Violet 4BNS
   * Acid Violet 6B
   * Acid Violet 5BN
   * Acid Violet S
   * Acilan Violet S4BN
   * A.F. Violet No. 1
   * Aizen Acid Violet 5BH
   * Aizen Food Violet No. 1
   * Benzyl Violet
   * Benzyl Violet 3B
   * Benzyl Violet 4B
   * Calcocid Violet 4BNS
   * C.I. 42640
   * C.I. Acid Violet 49
   * C.I. Acid Violet 49 (sodium salt)
   * C.I. Food Violet 2
   * Cogilor Violet 411.12
   * Coomassie Violet
   * Dispersed Violet 12197
   * Eriosin Violet 3B
   * Fast Acid Violet 5BN
   * FD and C Violet 1
   * Food Violet 2
   * Hidacid Wool Violet 5B
   * Intracid Violet 4BNS
   * Kiton Violet 4BNS
   * Pergacid Violet 2B
   * Pergacid Violet 3B
   * Polaxal Violet 6B
   * Solar Violet 5BN
   * Tertracid Brilliant Violet 6B
   * Violet 2
   * 11386 Violet
   * Violet 5B
   * Violet 6B
   * Violet 5BN
   * Violet kysela 49
   * Violet No. 1
   * Violet potravinarska 2
   * Wool Violet
   * Wool Violet 4BN
   * Wool Violet 5BN
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 498 gm/kg/28W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   51,1337,1973
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9360 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 16,367,1957
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 320 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,21,1981

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 16,153,1978

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 16,153,1978

   IARC Cancer Review:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   ARVPAX Annual Review of Pharmacology.  (Palo Alto, CA)  V.1-15, 1961-75. For
   publisher information, see ARPTDI.  Volume(issue)/page/year: 14,127,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2202
       No. of Facilities: 469 (estimated)
       No. of Industries: 9
       No. of Occupations: 28
       No. of Employees: 13175 (estimated)
   
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M3845
       No. of Facilities: 62 (estimated)
       No. of Industries: 3
       No. of Occupations: 11
       No. of Employees: 837 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M3845
       No. of Facilities: 406 (estimated)
       No. of Industries: 7
       No. of Occupations: 11
       No. of Employees: 4328 (estimated)
       No. of Female Employees: 808 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***