*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BQ1150000
CHEMICAL NAME           : Ammonium,
                          (4-(p-(dimethylamino)-alpha-(2-hydroxy-3,6-disulfo-1-
                          naphthyl)benzylidene) -2,5-
                          cyclohexadien-1-ylidene)dimethyl-, hydroxide, inner
                          salt, sodium salt
CAS REGISTRY NUMBER     : 3087-16-9
LAST UPDATED            : 199701
DATA ITEMS CITED        : 12
MOLECULAR FORMULA       : C27-H26-N2-O7-S2.Na
MOLECULAR WEIGHT        : 577.66
WISWESSER LINE NOTATION : L66J CO DSWQ HSWO BYR DN1&1&U- AL6Y DYJ DUK1&1 &-NA-
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Acidal Wool Green BS
   * Acid Brilliant Green BS
   * Acid Green 50
   * Acid Leather Green S
   * Acilan Green BS
   * Amacid Wool Green S
   * Brilliantsaeure gruen BS
   * Bucacid Wool Green
   * Calocid Green S
   * Calocid Green SB
   * C.I. 44090
   * C.I. Acid Green 50, monosodium salt
   * C.I. Food Green 4
   * E 142
   * Edicol Supra Green B
   * Erio Green S
   * Food Green S
   * Green 5
   * 12078 Green
   * Green BS
   * Green S
   * Hexacol Green S
   * Hidacid Wool Green
   * Kiton Green S
   * Lissamine Green B
   * Lissamine Green BN
   * Naphthazine Green S
   * Pharmacid Green S
   * Schultz Nr. 836
   * Sumitomo Wool Green S
   * Unitertracid Green BS
   * Vert acide brilliant BS
   * Vondacid Green S
   * Water Green SX
   * Wool Green 5
   * Wool Green B
   * Wool Green BS
   * Wool Green BSNA
   * Wool Green MS
   * Wool Green S
   * Wool Green S (biological stain)
   * Wool Green SG
   * Zelen kysela 50
   * Zelen kysela BS
   * Zelen potravinarska 4
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCPHA4 Scientia Pharmaceutica.  (Oesterreichische
   Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
   V.1-    1930-  Volume(issue)/page/year: 47,39,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 136 gm/kg/13W-C
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Kidney, Ureter, Bladder - urine volume increased
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   25,969,1987
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 470 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 46A,57,1969
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : female 0-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   25,995,1987
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,21,1981
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 2840 umol/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 19,419,1981
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,223,1992
 
TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,223,1992

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2207
       No. of Facilities: 18 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 175 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M2207
       No. of Facilities: 98 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 1378 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***