*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BQ1450000
CHEMICAL NAME           : Ammonium,
                          (6-(dimethylamino)-3H-xanten-3-ylidene)dimethyl-,
                          chloride
CAS REGISTRY NUMBER     : 92-32-0
LAST UPDATED            : 199701
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C17-H19-N2-O.Cl
MOLECULAR WEIGHT        : 302.83
WISWESSER LINE NOTATION : T C666 BO EYJ EUK1&1 MN1&1 &G
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * C.I. 45005
   * Methanaminium, N-(6-(dimethylamino)-3H-xanthen-3-ylidene)-N-methyl-,  
   chloride
   * Methyl pyronin
   * Pyronine
   * Pyronine G
   * Pyronine Y
   * Pyronine ZH
   * Pyronin G
   * Pyronin Y
   * Pyronin Yellow
   * Schultz No. 853
   * Tetramethyl pyronin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 179 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   44,225,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 80 ug/plate
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 27,153,1976
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ppm/5H
REFERENCE :
   CSHSAZ Cold Spring Harbor Symposia on Quantitative Biology.  (Cold Spring
   Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724)  V.1-    1933-
   Volume(issue)/page/year: 12,256,1947
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 2 mg/disc
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 27,153,1976
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1000 ppm
REFERENCE :
   AMNTA4 American Naturalist.  (Univ. of Chicago Press, Journals Div., POB
   37005, Chicago, IL 60637) V.1-    1867-  Volume(issue)/page/year:
   87,295,1953

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7179
       No. of Facilities: 63 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 1056 (estimated)
       No. of Female Employees: 810 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; D melanogaster
   Sex-linked lethal
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***