*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BQ4375000
CHEMICAL NAME           : Ammonium,
                          ethyl(4-(p-(ethyl(m-sulfobenzyl)amino)-alpha-phenylbe
                          nzylidene)-
                          2,5-cyclohexadien-1-ylidene)(m-sulfobenzyl)-,
                          hydroxide, inner salt, sodium salt
CAS REGISTRY NUMBER     : 4680-78-8
LAST UPDATED            : 199710
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C37-H36-N2-O6-S2.Na
MOLECULAR WEIGHT        : 691.86
WISWESSER LINE NOTATION : L6Y DYJ AUYR&R DN2&1R CSWQ&& DUK2&1R CSWQ &Q &-NA-
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acidal Green G
   * Acid Green 3
   * Acid Green
   * Acid Green B
   * Acid Green 2G
   * Acid Green G
   * Acid Green L
   * Acid Green S
   * Acid Leather Green F
   * Acid Leather Green 3G
   * Acilan Green B
   * A.F. Green No. 1
   * Amacid Green B
   * Brilliant Green 3EMBL
   * Bucacid Guinea Green BA
   * Calcocid Green G
   * C.I. 42085
   * C.I. Acid Green 3
   * C.I. Acid Green 3, monosodium salt
   * C.I. Acid Green 3, sodium salt
   * C.I. Food Green 1
   * FD and C Green No. 1
   * FDC Green 1
   * Fenazo Green L
   * Food Green 1
   * Guinea Green
   * Guinea Green B
   * Guinea Green BA
   * Hidacid Emerald Green
   * Hispacid Green GB
   * Intracid Green F
   * Kiton Green F
   * Kiton Green FC
   * Leather Green B
   * Lissamine Green G
   * Merantine Green G
   * Naphthalene Green G
   * Naphthalene Lake Green G
   * Naphthalene Leather Green G
   * Neran Brilliant Green G
   * Pontacyl Green BL
   * Sulfacid Brilliant Green 1B
   * Sulpho Green 2B
   * Vondacid Green L
   * Zelen kysela 3
   * Zelen potravinarska 1
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 7(2),54,1963
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 100 mg/m3/13W-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 7(2),54,1963
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 660 gm/kg/43W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   GASTAB Gastroenterology.  (Academic Press, Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1943-  Volume(issue)/page/year: 23,1,1953
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 320 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,21,1981

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Limited Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 16,199,1978

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 16,199,1978

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   ARVPAX Annual Review of Pharmacology.  (Palo Alto, CA)  V.1-15, 1961-75. For
   publisher information, see ARPTDI.  Volume(issue)/page/year: 14,127,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2189
       No. of Facilities: 183 (estimated)
       No. of Industries: 4
       No. of Occupations: 18
       No. of Employees: 2742 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M2189
       No. of Facilities: 400 (estimated)
       No. of Industries: 3
       No. of Occupations: 13
       No. of Employees: 5996 (estimated)
       No. of Female Employees: 3818 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***