*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BQ4550000
CHEMICAL NAME           : Ammonium,
                          ethyl(4-(p-(ethyl(m-sulfobenzyl)amino)-alpha-(o-sulfo
                          phenyl)benzylidene)-
                          2,5-cyclohexadien-1-ylidene)(m-sulfobenzyl)-,
                          hydroxide, inner salt, diammonium salt
CAS REGISTRY NUMBER     : 2650-18-2
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C37-H36-N2-O9-S3.2H3-N
MOLECULAR WEIGHT        : 783.01
WISWESSER LINE NOTATION : L6Y DYJ AUYR BSWQ&R DN2&1R CSWQ&& DUK2&1R CSWQ &Q &ZH
                          2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Acid Blue 9
   * Acilan Turquoise Blue AE
   * A.F. Blue No. 1
   * Aizen Brilliant Blue FCF
   * Alphazurine
   * Alphazurine FG
   * Alphazurine FGND
   * Alphazurine (indicator)
   * Amacid Blue FG Conc
   * Bleu Brilliant FCF
   * 11388 Blue
   * Brilliant Blue
   * Bucacid Azure Blue
   * Calcocid Blue EG
   * Calcocid Blue 2G
   * C.I. 42090
   * C.I. Acid Blue 9
   * C.I. Acid Blue 9, diammonium salt
   * C.I. Food Blue 2
   * D and C Blue No. 4
   * Disulphine Lake Blue EG
   * Duasyn Acid Blue AE
   * Edicol Supra Blue E6
   * Erioglaucine
   * Erioglaucine A
   * Erioglaucine E
   * Eriosky Blue
   * Fenazo Blue XR
   * Food Blue 1
   * Hidacid Azure Blue
   * H.K. Formula No. K. 7117
   * Kiton Blue AR
   * Kiton Pure Blue L
   * Maple Brilliant Blue FCF
   * Neptune Blue BRA
   * Orient Water Blue 9
   * Patent Blue AE
   * Patent Blue 2Y
   * Peacock Blue X-1756
   * Triantine Light Brown 3RN
   * Water Blue 9
   * Xylene Blue VSG
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 33 ug/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,87,1969
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg/77W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,29,1966
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3333 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 189,223,1987
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 200 umol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,101,1985
 
TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,101,1985
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 571 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 189,223,1987
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 5 gm/L
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   22,623,1984

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   ARVPAX Annual Review of Pharmacology.  (Palo Alto, CA)  V.1-15, 1961-75. For
   publisher information, see ARPTDI.  Volume(issue)/page/year: 14,127,1974

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
   FEREAC Federal Register.  (U.S. Government Printing Office, Supt. of
   Documents, Washington, DC 20402) V.1-    1936-  Volume(issue)/page/year:
   54,7740,1989

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2196
       No. of Facilities: 811 (estimated)
       No. of Industries: 20
       No. of Occupations: 27
       No. of Employees: 17059 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M2196
       No. of Facilities: 2902 (estimated)
       No. of Industries: 26
       No. of Occupations: 41
       No. of Employees: 96076 (estimated)
       No. of Female Employees: 62671 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; Histidine
   reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***