*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SM8380000 CHEMICAL NAME : Phenolphthalein CAS REGISTRY NUMBER : 77-09-8 OTHER CAS REGISTRY NOS. : 467-29-8 57214-20-7 BEILSTEIN REFERENCE NO. : 0284423 REFERENCE : 5-18-04-00188 (Beilstein Handbook Reference) LAST UPDATED : 199803 DATA ITEMS CITED : 20 MOLECULAR FORMULA : C20-H14-O4 MOLECULAR WEIGHT : 318.34 WISWESSER LINE NOTATION : T56 BVO DHJ D- D-/R DQ 2 COMPOUND DESCRIPTOR : Agricultural Chemical Tumorigen Mutagen Human SYNONYMS/TRADE NAMES : * Agoral * Alophen * 3,3-Bis(p-hydroxyphenyl)phthalide * Colax * Correctol * Dialose * alpha-Di(p-hydroxyphenyl)phthalide * Dihydroxyphthalophenone * Doxidan * Euchessina * Evac-Q-Kit * Evac-Q-Kwik * Evac-U-Gen * Evac-V-Lax * Ex-Lax * Feen-a-mint gum * FemiLax * Fenolftalein * alpha-(p-Hydroxyphenyl)-alpha-(4-oxo-2,5-cyclohexadien-1-ylidene)-o-tolu ic acid * 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)- * Kondremul * Koprol * Laxogen * LaxCaps * Lax-Pills * Lilo * Medilax * Modane * NCI-C55798 * Phenolax * Phthalide 3,3,-bis(p-hydroxyphenyl)- * Phthalimetten * Phthalin * Prulet * Purga * Purgen * Purgophen * Spulmako-lax * Trilax *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Gastrointestinal - gastritis Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - other changes in urine composition REFERENCE : PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 60,491,1984 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,25,1953 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,30,1953 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 324 gm/kg/13W-C TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,48,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 106 gm/kg/13W-C TOXIC EFFECTS : Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 18,48,1992 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 364 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - adrenal cortex tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 281 gm/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996 ** MUTATION DATA ** TYPE OF TEST : Micronucleus test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 1680 mg/kg/14D (Continuous) REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 50 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,151,1995 *** REVIEWS *** TOXICOLOGY REVIEW DAPOAG Deutsche Apotheker. (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep. Ger.) V.1- 1949- Volume(issue)/page/year: 27,151,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0011 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 31 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 56240 No. of Facilities: 6160 (estimated) No. of Industries: 102 No. of Occupations: 43 No. of Employees: 43092 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9187 No. of Facilities: 117 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1946 (estimated) No. of Female Employees: 1408 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 56240 No. of Facilities: 6900 (estimated) No. of Industries: 89 No. of Occupations: 57 No. of Employees: 73297 (estimated) No. of Female Employees: 18309 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP Carcinogenesis Studies (feed);clear evidence:mouse NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996 NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-465,1996 *** END OF RECORD ***