*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SM8380000
CHEMICAL NAME           : Phenolphthalein
CAS REGISTRY NUMBER     : 77-09-8
OTHER CAS REGISTRY NOS. : 467-29-8
                          57214-20-7
BEILSTEIN REFERENCE NO. : 0284423
REFERENCE               : 5-18-04-00188 (Beilstein Handbook Reference)
LAST UPDATED            : 199803
DATA ITEMS CITED        : 20
MOLECULAR FORMULA       : C20-H14-O4
MOLECULAR WEIGHT        : 318.34
WISWESSER LINE NOTATION : T56 BVO DHJ D- D-/R DQ 2
COMPOUND DESCRIPTOR     : Agricultural Chemical
                          Tumorigen
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Agoral
   * Alophen
   * 3,3-Bis(p-hydroxyphenyl)phthalide
   * Colax
   * Correctol
   * Dialose
   * alpha-Di(p-hydroxyphenyl)phthalide
   * Dihydroxyphthalophenone
   * Doxidan
   * Euchessina
   * Evac-Q-Kit
   * Evac-Q-Kwik
   * Evac-U-Gen
   * Evac-V-Lax
   * Ex-Lax
   * Feen-a-mint gum
   * FemiLax
   * Fenolftalein
   *   alpha-(p-Hydroxyphenyl)-alpha-(4-oxo-2,5-cyclohexadien-1-ylidene)-o-tolu
     ic acid
   * 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-
   * Kondremul
   * Koprol
   * Laxogen
   * LaxCaps
   * Lax-Pills
   * Lilo
   * Medilax
   * Modane
   * NCI-C55798
   * Phenolax
   * Phthalide 3,3,-bis(p-hydroxyphenyl)-
   * Phthalimetten
   * Phthalin
   * Prulet
   * Purga
   * Purgen
   * Purgophen
   * Spulmako-lax
   * Trilax
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - gastritis
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 60,491,1984
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,25,1953
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,30,1953
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 324 gm/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,48,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 106 gm/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - changes in erythrocyte (RBC) count
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   18,48,1992
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Endocrine - adrenal cortex tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 281 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1680 mg/kg/14D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,151,1995
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 341,151,1995

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   DAPOAG Deutsche Apotheker.  (Postfach 1650, 6370 Oberusel/Taunas, Fed. Rep.
   Ger.)  V.1-    1949-  Volume(issue)/page/year: 27,151,1975

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - T0011
       No. of Facilities: 8 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 31 (estimated)
   
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 56240
       No. of Facilities: 6160 (estimated)
       No. of Industries: 102
       No. of Occupations: 43
       No. of Employees: 43092 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X9187
       No. of Facilities: 117 (estimated)
       No. of Industries: 3
       No. of Occupations: 6
       No. of Employees: 1946 (estimated)
       No. of Female Employees: 1408 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 56240
       No. of Facilities: 6900 (estimated)
       No. of Industries: 89
       No. of Occupations: 57
       No. of Employees: 73297 (estimated)
       No. of Female Employees: 18309 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NTP Carcinogenesis Studies (feed);clear evidence:mouse
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996

   NTP Carcinogenesis Studies (feed);some evidence:rat
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-465,1996

 
                            *** END OF RECORD ***