*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SN5425000 CHEMICAL NAME : 3H-Phenothiazine, 7-amino-3-imino-, monohydrochloride CAS REGISTRY NUMBER : 581-64-6 LAST UPDATED : 199701 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C12-H10-N3-S.Cl MOLECULAR WEIGHT : 263.76 WISWESSER LINE NOTATION : T C666 BN ISJ FZ IG LZ COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * C.I. 52000 * Cyanine * 3,7-Diaminophenazathionium chloride * Katalysin * Lauthsches violett * Lauth's Violet * Phenothiazin-5-ium, 3,7-diamino-, chloride * Thionin * Thionine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 215 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 204,288,1947 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7400 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8030 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 mg/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976 TYPE OF TEST : DNA repair TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 2 mg/disc REFERENCE : TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50- Volume(issue)/page/year: 27,153,1976 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***