*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SN5446000
CHEMICAL NAME           : 10H-Phenothiazine,
                          10-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)ace
                          tyl)-, hydrochloride
LAST UPDATED            : 199603
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C26-H25-N3-O3-S.Cl-H
MOLECULAR WEIGHT        : 496.06
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   *   10-((4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)acetyl)-10H-phenothiaz
     ine hydrochloride
   * Chlorhydrate de piperonyl piperazino-acetyl-10 phenothiazine
   * Fenoverine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 12857 ug/kg/3D-I
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Liver - liver function tests impaired
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 14,654,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 48 mg/kg/4D-I
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Kidney, Ureter, Bladder - renal function tests depressed
REFERENCE :
   HETOEA Human & Experimental Toxicology.  (Macmillan Press Ltd., Brunel Road,
   Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
   Volume(issue)/page/year: 14,654,1995
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRXXBL French Demande Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2092639
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRXXBL French Demande Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2092639
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRXXBL French Demande Patent Document.  (U.S. Patent and Trademark Office,
   Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year: #2092639
 
                            *** END OF RECORD ***