*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SN7350000 CHEMICAL NAME : Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, hydrochloride CAS REGISTRY NUMBER : 298-51-1 LAST UPDATED : 199803 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C19-H22-N2-O2-S.Cl-H MOLECULAR WEIGHT : 378.95 WISWESSER LINE NOTATION : T C666 BN ISJ BVO2N2&2 &GH COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * beta-Diethylaminoethyl phenothiazine-N-carboxylate hydrochloride * beta-Diethylaminoethyl phenothiazine-10-carboxylate hydrochloride * Novazin * Novazin hydrochloride * 10-Phenothiazinecarboxylic acid beta-diethylaminoethyl ester hydrochloride * Phenothiazine-10-carboxylic acid, 2-(diethylamino)ethyl ester, monohydrochloride * Transergan *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 440 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - convulsions or effect on seizure threshold REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 13,59,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - convulsions or effect on seizure threshold REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 13,59,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Behavioral - sleep Behavioral - convulsions or effect on seizure threshold REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 13,59,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 26 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 90,241,1952 *** END OF RECORD ***