*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SN7525000
CHEMICAL NAME           : Phenothiazine-10-carboxylic acid,
                          2-(2-(dimethylamino)ethoxy)ethyl ester,
                          monohydrochloride
CAS REGISTRY NUMBER     : 518-63-8
LAST UPDATED            : 199106
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H22-N2-O3-S.Cl-H
MOLECULAR WEIGHT        : 394.95
WISWESSER LINE NOTATION : T C666 BN ISJ BVO2O2N1&1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Cothera
   * Dimethoxanate hydrochloride
   * 2-(2-(Dimethylamino)ethoxy)ethyl phenothiazine-10-carboxylate  
   hydrochloride
   * beta-Dimethylaminoethoxyethyl phenothiazine-10-carboxylate hydrochloride
   * Dimetoxanate hydrochloride
   * Ethanol, 2-(2-(dimethylamino)ethoxy)-, phenothiazine-10-carboxylate  
   (ester), hydrochloride
   * Phenothiazine-10-carboxylic acid 2-(2-(dimethylamino)ethoxy)ethyl ester  
   hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,43,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,43,1969
 
                            *** END OF RECORD ***