*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SO3150000 CHEMICAL NAME : Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, maleate (1:2) CAS REGISTRY NUMBER : 84-02-6 LAST UPDATED : 199703 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C20-H24-Cl-N3-S.2C4-H4-O4 MOLECULAR WEIGHT : 606.14 WISWESSER LINE NOTATION : T C666 BN ISJ EG B3- AT6N DNTJ D1 &OV1U1VO COMPOUND DESCRIPTOR : Drug Human SYNONYMS/TRADE NAMES : * Buccastem * 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine, dimaleate * 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine dimaleate * Compazine * Emetiral * Meterazin maleate * Nibromin A * Pasotomin * 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2) * Prochloroproazine hydrogen maleate * Prochlorperazine bimaleate * Prochlorperazine dimaleate * Prochlorperazine hydrogen maleate * Prochlorperazine maleate * Prochlorperazinu dimaleat * Stemetil dimaleate * Vertigon *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 600 ug/kg/18H-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - muscle contraction or spasticity REFERENCE : SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 84,407,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,78,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 191 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSYPAG Psychopharmacologia (Berlin). (Berlin, Ger.) V.1-46, 1959-76. For publisher information, see PSCHDL. Volume(issue)/page/year: 12,142,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,40,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 85 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 12,445,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5607 No. of Facilities: 84 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 4587 (estimated) No. of Female Employees: 4212 (estimated) *** END OF RECORD ***