*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SO3675000
CHEMICAL NAME           : Phenothiazine,
                          10-(3-(diallylamino)propyl)-2-(trifluromethyl)-
CAS REGISTRY NUMBER     : 63834-03-7
LAST UPDATED            : 199506
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H23-F3-N2-S
MOLECULAR WEIGHT        : 404.53
WISWESSER LINE NOTATION : T C666 BN ISJ B3N2U1&2U1 EXFFF
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * NDR A-3528
   * 2-Trifluoromethyl-10-(diallylaminopropyl)phenothiazine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1149 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 977 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 242 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962
 
                            *** END OF RECORD ***