*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SO7600000
CHEMICAL NAME           : Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
CAS REGISTRY NUMBER     : 61-01-8
LAST UPDATED            : 198209
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H22-N2-O-S
MOLECULAR WEIGHT        : 314.48
WISWESSER LINE NOTATION : T C666 BN ISJ B3N1&1 EO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 10-(3-Dimethylaminopropyl)-2-methoxyphenothiazine
   * Methopromazine
   * 2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
   * Methoxypromazine
   * 2-Methoxypromazine
   * Mopazin
   * Mopazine
   * Neoproma
   * RP 4632
   * Tenton
   * Tentone
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 730 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 125,101,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 125,101,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 408 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 125,101,1960
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 125,101,1960

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JMSCA9 Journal of Mental Science.  (London, UK)  V.4-108, 1857-1962.  For
   publisher information, see BJPYAJ.  Volume(issue)/page/year: 106,755,1960

 
                            *** END OF RECORD ***