*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SP0875000
CHEMICAL NAME           : Phenothiazine,
                          2-methoxy-10-(2-(1-methyl-2-piperidyl)ethyl)-
CAS REGISTRY NUMBER     : 14759-04-7
BEILSTEIN REFERENCE NO. : 6118065
REFERENCE               : 4-27-00-02038 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C21-H26-N2-O-S
MOLECULAR WEIGHT        : 354.55
WISWESSER LINE NOTATION : T C666 BN ISJ EO1 B2- BT6NTJ A1
SYNONYMS/TRADE NAMES :
   * KS-33
   * 2-Methoxy-10-(2-(1-methyl-2-piperidyl)ethyl)phenothiazine
   * 3-Methoxy-10-(2'-(N-methylpiperidyl-2')-ethyl)phenothiazine
   * Oxyridazine
   * 10H-Phenothiazine, 2-methoxy-10-(2-(1-methyl-2-piperidyl)ethyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
   D.H. Efron, Washington, DC, 1972  Volume(issue)/page/year: -,27,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIGZAY Niigata Igakkai Zasshi.  Niigata Medical Journal.  (Niigata Igakkai,
   1, Asahi-machi, Niigata 951, Japan)  V.60-    1946- Volume(issue)/page/year:
   82,607,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 516 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   65(2),104S,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   65(2),104S,1969
 
                            *** END OF RECORD ***