*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SP2625000
CHEMICAL NAME           : Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-
CAS REGISTRY NUMBER     : 60-89-9
LAST UPDATED            : 199707
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C19-H22-N2-S
MOLECULAR WEIGHT        : 310.49
WISWESSER LINE NOTATION : T C666 BN ISJ B1- CT6NTJ A1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Lacumin
   * Mepazin
   * Mepazine
   * Mepazine Base
   * Meprazine
   * (N-Methyl-3-piperidyl)methylphenothiazine
   * 10-(1-Methylpiperidyl-3-methyl)phenothiazine
   * 10-(1-Methyl-3-piperidyl)methyl phenothiazine
   * MPMP
   * Nothiazine
   * P 391
   * Pacatal
   * Pacatal Base
   * Pakatal
   * Paxital
   * Pecatal
   * Pecazine
   * 10H-Phenothiazine, 10-((1-methyl-3-piperazinyl)methyl)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 24,136,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,489,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CANJAE Canadian Anaesthetists' Society Journal.  (Toronto, Ont., Canada)
   V.1-33, 1954-86.  Volume(issue)/page/year: 3,224,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 4,232,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CANJAE Canadian Anaesthetists' Society Journal.  (Toronto, Ont., Canada)
   V.1-33, 1954-86.  Volume(issue)/page/year: 3,224,1956

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   JMSCA9 Journal of Mental Science.  (London, UK)  V.4-108, 1857-1962.  For
   publisher information, see BJPYAJ.  Volume(issue)/page/year: 106,755,1960

 
                            *** END OF RECORD ***