*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SP3325000 CHEMICAL NAME : Phenothiazine, 10-(3-(beta-morpholinoethylamino)propyl)-2-trifluorom ethyl-, dihydrochloride CAS REGISTRY NUMBER : 3772-70-1 LAST UPDATED : 199712 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H26-F3-N3-O-S.2Cl-H MOLECULAR WEIGHT : 510.49 WISWESSER LINE NOTATION : T C666 BN ISJ EXFFF B3N2&- AT6N DOTJ &GH 2 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * NDR 3680A * NDR-A 3680 * 2-Trifluoromethyl-10-(3-(beta-morpholinoethylamino)propyl)phenothiazine dihydrochloride *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 616 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - rigidity (including catalepsy) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 136,476,1962 *** END OF RECORD ***