*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SP3325000
CHEMICAL NAME           : Phenothiazine,
                          10-(3-(beta-morpholinoethylamino)propyl)-2-trifluorom
                          ethyl-, dihydrochloride
CAS REGISTRY NUMBER     : 3772-70-1
LAST UPDATED            : 199712
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H26-F3-N3-O-S.2Cl-H
MOLECULAR WEIGHT        : 510.49
WISWESSER LINE NOTATION : T C666 BN ISJ EXFFF B3N2&- AT6N DOTJ &GH 2
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * NDR 3680A
   * NDR-A 3680
   * 2-Trifluoromethyl-10-(3-(beta-morpholinoethylamino)propyl)phenothiazine  
   dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 616 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 136,476,1962
 
                            *** END OF RECORD ***