*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SP4725000
CHEMICAL NAME           : Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-
CAS REGISTRY NUMBER     : 84-08-2
LAST UPDATED            : 199510
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H20-N2-S
MOLECULAR WEIGHT        : 296.46
WISWESSER LINE NOTATION : T C666 BN ISJ B2- AT5NTJ
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Parathiazine
   * Pyrathiazine
   * Pyrrolidine, 1-(2-phenothiazin-10-ylethyl)-
   * Pyrrolidino-aethyl-phenthiazin
   * N-(beta-Pyrrolidinoethyl)phenothiazine
   * 10-(2-(1-Pyrrolidinyl)ethyl)phenothiazine
   * 10-(2-(1-Pyrrolidyl)ethyl)phenothiazine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 707 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,237,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 7,237,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   43FLAV "Burger's Medicinal Chemistry," 4th ed., Wolff, M.E., ed., New York,
   John Wiley & Sons, Inc., 1980  Volume(issue)/page/year: 4(3),569,1980
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 450 mg/kg
SEX/DURATION            : female 6-8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Fertility - abortion
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 89,629,1955
 
                            *** END OF RECORD ***