*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SP4725000 CHEMICAL NAME : Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)- CAS REGISTRY NUMBER : 84-08-2 LAST UPDATED : 199510 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H20-N2-S MOLECULAR WEIGHT : 296.46 WISWESSER LINE NOTATION : T C666 BN ISJ B2- AT5NTJ COMPOUND DESCRIPTOR : Reproductive Effector SYNONYMS/TRADE NAMES : * Parathiazine * Pyrathiazine * Pyrrolidine, 1-(2-phenothiazin-10-ylethyl)- * Pyrrolidino-aethyl-phenthiazin * N-(beta-Pyrrolidinoethyl)phenothiazine * 10-(2-(1-Pyrrolidinyl)ethyl)phenothiazine * 10-(2-(1-Pyrrolidyl)ethyl)phenothiazine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 707 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 190 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,237,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 43FLAV "Burger's Medicinal Chemistry," 4th ed., Wolff, M.E., ed., New York, John Wiley & Sons, Inc., 1980 Volume(issue)/page/year: 4(3),569,1980 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 450 mg/kg SEX/DURATION : female 6-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 89,629,1955 *** END OF RECORD ***