*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : SP5660000 CHEMICAL NAME : Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride CAS REGISTRY NUMBER : 531-53-3 OTHER CAS REGISTRY NOS. : 959-03-5 8000-86-0 LAST UPDATED : 199709 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C14-H14-N3-S.Cl MOLECULAR WEIGHT : 291.82 WISWESSER LINE NOTATION : T C666 BN ISJ FZ MN1&1 &G &12/25 COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 3-Amino-7-(dimethylamino)phenothiazin-5-ium chloride * Azure A * Azur A * C.I. 52005 * asym-Dimethyl-3,7-diaminophenazathionium chloride * Dimethylthionine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 37720 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 59040 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 19340 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : SMBUA9 Stanford Medical Bulletin. (Palo Alto, CA) V.1-20, 1942-62. Discontinued. Volume(issue)/page/year: 9,96,1951 ** MUTATION DATA ** TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 20 umol/L/5H (Continuous) REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3031 No. of Facilities: 451 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 2020 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3031 No. of Facilities: 661 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 5132 (estimated) No. of Female Employees: 2765 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***