*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : SP5670000
CHEMICAL NAME           : Phenothiazin-5-ium,
                          3-amino-7-(dimethylamino)-2-methyl-, chloride
CAS REGISTRY NUMBER     : 92-31-9
LAST UPDATED            : 199706
DATA ITEMS CITED        : 13
MOLECULAR FORMULA       : C15-H16-N3-S.Cl
MOLECULAR WEIGHT        : 305.85
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Blutene chloride
   * C.I. Basic Blue 17
   * Dimethyltoluthionine chloride
   * F Klot
   * Gabilin
   * Klot
   * Menodin
   * Modr Toluidinova
   * Modr Zasadita 17
   * Schultz 1041
   * Tolazul
   * Tolonium chloride
   * Toluidinblau
   * Toluidine Blue
   * Toluidine Blue O
   * Toluidine Blue OO
   * Toluidine Blue (phenothiazine dye)
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 43 mg/kg/6D
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - other changes
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,597,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 215 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 204,288,1947
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28930 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27560 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 28 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,902,1974
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 13440 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   SMBUA9 Stanford Medical Bulletin.  (Palo Alto, CA)  V.1-20, 1942-62.
   Discontinued.  Volume(issue)/page/year: 9,96,1951
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 279,255,1992
 
TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 500 ppm
REFERENCE :
   14ZYA8 "Induction of Mutations and the Mutation Process, Proceedings of a
   Symposium, Prague, Czechoslovakia, 1963," Veleminsky, J., and T. Gichnar,
   eds., Prague, Academia, 1965  Volume(issue)/page/year: -,115,1965
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 20 umol/L/5H (Continuous)
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 1,27,1979

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - A1164
       No. of Facilities: 224 (estimated)
       No. of Industries: 3
       No. of Occupations: 4
       No. of Employees: 1226 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - A1164
       No. of Facilities: 196 (estimated)
       No. of Industries: 1
       No. of Occupations: 4
       No. of Employees: 7956 (estimated)
       No. of Female Employees: 5824 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; S cerevisiae
   gene conversion
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***